양극산화 표면처리한 티타늄 임플랜트를 난소절제한 백서 경골에 매식 후 주위 골형성에 관한 연구
The bone formation around anodic oxidized titanium implants in the tinbiae of ovarectomized rats
박성환, 정석영, 이재열, 김규천, 신상훈,
소속 상세정보
박성환 ( Park Sung-Hwan ) - 수부부치과의원
정석영 ( Jeong Seok-Young ) - 부산대학교 치의학전문대학원 구강악안면외과학교실
이재열 ( Lee Jae-Yeol ) - 부산대학교 치의학전문대학원 구강악안면외과학교실
김규천 ( Kim Gyoo-Cheon ) - 부산대학교 치의학전문대학원 구강해부학교실
신상훈 ( Shin Sang-Hun ) - 부산대학교 치과대학 구강안면외과학교실
KMID : 0355620080340030306
Abstract
Anodic spark deposition method(ASD) surface treated titanium implant possesses a considerable osteoconductive potential that promoting a high level of implant osseointegration in normal bone. The purpose of this study was to observe the ASD implant’s osseointegration in the osteoporosis-induced animal model. Twenty four rats, 10 weeks of age, were ovarectomized and 5 weeks later divided into two groups : ASD implant group and control implant group. Titanium screw implants (diameter; 2.0 ㎜, length, 3.5 ㎜; pitch-height, 0.4 ㎜) were designed for this study. Experimental implants were ASD treated and no treatment on control implants. ASD implants and control implants were placed in to left tibiae of rats. The rats were sacrificed at different time interval(1, 2, 4 and 8 weeks after implantation) for histopathologic observation and immunohisto -chemistrical observation, with collagen type Ⅰ, fibronectin, integrin ?2?1 and integrin ?5?1 antibodies. The results obtained from this study were as follow: 1. Histopathologic findings, overall tissue response and the pattern of bone formation in both groups were similar. In ASD group, more newly formed bone was seen at 1 week and 2weeks than control group. 2. The levels of type Ⅰ collagen and fibronectin expression were the most abundant at 2weeks and decreased gradually in both groups. Fibronectin and type Ⅰ collagen expression in ASD group were stronger than control group but no significance. 3. The levels of integrin ?2?1 and Integrin ?5?1 expression were most abundant at 2 weeks and decreased gradually in both groups. No significant difference was observed in both groups. From this results, anodic oxidized titanium implants were more advantages in early stage of bone formation than control group, but have no significance in tissue responses and late bone formations. It could be stated that although anodic oxidized titanium implant possesses considerable osteoconductive potential but in osteoporotic bone condition dental implant procedure should performed after improving or treating the osteoporotic bone condition.
키워드
Anodic oxidation(anodization);Osteoporosis; Bone healing; Dental implants
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